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Basal ganglia: Function and dysfunction

Basal ganglia: Function and dysfunction

This research direction aims at understanding the function of basal ganglia pathways. Our computational models implement multiple basal ganglia pathways and update their impact by learning rules. This allows to also address changes of pathway impacts by modeling the changes of factors in those learning rules.

Funding

German Research Foundation (DFG HA2630/7-1), DFG Klinische Forschergruppe Tiefe Hirnstimulation: Wirkmechanismus, Kortex-Basalganglien-Physiologie und Therapieoptimierung
German Research Foundation (DFG HA2630/8-1), German-Japanese Collaboration Computational Neuroscience

Selected Publications

Schroll H., Hamker, F.H. (2013)
Computational models of basal-ganglia pathway functions: Focus on functional neuroanatomy
Frontiers in Systems Neuroscience,doi: 10.3389/fnsys.2013.00122
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Schroll, H., Vitay, J., Hamker, F.H. (2013)
Dysfunctional and Compensatory Synaptic Plasticity in Parkinson's Disease.
European Journal of Neuroscience, doi:10.1111/ejn.12434.
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Verleger R., Schroll H., Hamker F.H. (2013)
The Unstable Bridge from Stimulus Processing to Correct Responding in Parkinson's Disease
Neuropsychologia, 51(13):2512-2525.
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